PGC 1 Induces Susceptibility To Acetaminophen Driven Acute Liver Failure Scientific Reports Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize As a naturopathic doctor and a mom, Tylenol is a hard no in my house and I want to explain why. , , Acetaminophen (Tylenol) is processed through the liver, and in that process it can lower Deciphering Acetaminophen Induced Hepatotoxicity: The Crucial Role of Transcription Factors like Nuclear Factor Erythroid 2Related Factor 2 as Genetic Determinants of Susceptibility to Drug Induced Liver Injury Drug Metabolism and Disposition